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It is also used in some patients after a heart attack Drug Interactions. 5 mg hydrochlorothiazide once a day. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Your doctor may adjust your dose as needed. National Library of Medicine, drugs that may interact with lisinopril include, but are not limited to, the following. Created for people with ongoing healthcare needs but benefits everyone Lisinopril works by blocking a substance in the body that causes the blood vessels to tighten. You can take lisinopril with or without food. Your blood pressure will need to be checked often. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. 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